RESUMO Introdução O sucesso no esporte depende do potencial do atleta, incluindo da presença de doenças crônicas que podem afetar negativamente uma carreira esportiva. A questão estudada é complexa e sua solução depende de uma combinação de fatores que atuam como componentes basais. A relevância do tema de pesquisa mencionado neste caso é determinada pela necessidade de estudar a relação entre estes dois fatores no contexto de sua influência mútua sobre as perspectivas de desenvolvimento da carreira esportiva de um indivíduo. Objetivo O objetivo deste estudo científico é estabelecer uma relação entre as capacidades esportivas e o potencial atlético em um indivíduo portador de doenças crônicas. Métodos A abordagem principal deste estudo foi uma combinação de análise sistêmica da relação entre vários aspectos do talento de um indivíduo com o desenvolvimento de sua carreira esportiva, uma compreensão teórica da relação deste fator e da influência de doenças crônicas na atividade esportiva. Resultados Os principais resultados obtidos no decorrer deste estudo científico devem ser considerados segundo a determinação da dependência da qualidade das realizações de um atleta em relação a seu talento natural e a influência das doenças crônicas. Conclusão As perspectivas de futuras pesquisas científicas nesta direção são determinadas por uma real necessidade de busca e aplicação prática de métodos para determinar a dependência das conquistas esportivas de fatores incluídos no tema deste trabalho científico. O valor aplicado deste estudo científico encontra-se na possibilidade de aplicação prática de seus resultados, com o objetivo de formar tais métodos para futuras abordagens. Evidência nível II; Estudos terapêuticos - pesquisa de resultados.

ABSTRACT Introduction Success in sports depends on the athlete’s potential, including the presence of chronic diseases that can negatively affect a sports career. The issue studied is complex, and its solution depends on a combination of factors that act as basal components. The relevance of the research topic mentioned here is determined by the need to study the relationship between these two factors in the context of their mutual influence on an individual’s sports career development prospects. Objective This scientific study aims to establish a relationship between sports skills and athletic potential in an individual with chronic diseases. Methods The main approach of this study was a combination of systemic analysis of the relationship between various aspects of an individual’s talent with the development of his sports career, a theoretical understanding of the relationship of this factor, and the influence of chronic diseases on sport activity. Results The main results obtained in this scientific study should be considered the determination of the quality of an athlete’s achievements on his natural talent and the influence of chronic diseases. Conclusion The prospects for future scientific research in this direction are determined by a real need for the search for and practical application of methods to determine the dependence of sporting achievements on factors included in the theme of this scientific work. The applied value of this scientific study lies in the possibility of the practical application of its results to form such methods for future approaches. Evidence level II; Therapeutic studies - outcomes research.

RESUMEN Introducción El éxito en el deporte depende del potencial del atleta, incluyendo la presencia de enfermedades crónicas que pueden afectar negativamente a la carrera deportiva. La cuestión estudiada es compleja y su solución depende de una combinación de factores que actúan como componentes basales. La pertinencia del tema de investigación mencionado en este caso viene determinada por la necesidad de estudiar la relación entre estos dos factores en el contexto de su influencia mutua en las perspectivas de desarrollo de la carrera deportiva de un individuo. Objetivo El objetivo de este estudio científico es establecer una relación entre las habilidades deportivas y el potencial atlético en un individuo con enfermedades crónicas. Métodos El enfoque principal de este estudio fue una combinación de análisis sistémico de la relación entre varios aspectos del talento de un individuo con el desarrollo de su carrera deportiva, una comprensión teórica de la relación de este factor y la influencia de las enfermedades crónicas en la actividad deportiva. Resultados Los principales resultados obtenidos en el curso de este estudio científico deben considerarse según la determinación de la dependencia de la calidad de los logros de un atleta de su talento natural y la influencia de las enfermedades crónicas. Conclusión Las perspectivas de futuras investigaciones científicas en esta dirección están determinadas por una necesidad real de búsqueda y aplicación práctica de métodos para determinar la dependencia de los logros deportivos de los factores incluidos en el tema de este trabajo científico. El valor aplicado de este estudio científico reside en la posibilidad de aplicación práctica de sus resultados, con el objetivo de formar dichos métodos para futuros planteamientos. Nivel de evidencia II; Estudios terapéuticos - investigación de resultados.

ABSTRACT Purpose: Diabetes mellitus is a serious health problem worldwide, and diabetic nephropathy is the complication. The diabetic nephropathy considerably enhances the oxidative stress, glycation, lipid parameters and inflammatory reaction. Ellipticine has potent free radical scavenging and anti-inflammatory effect. Methods: In the current study, our objectives were to thoroughly examine the renal protective effects of ellipticine in a rat model of streptozotocin (STZ)-induced diabetic nephropathy (DN) and to elucidate the underlying mechanisms involved. For the induction of diabetic nephropathy, streptozotocin (50 mg/kg) was used, and rats were separated into groups and given varying doses of ellipticine (2.5, 5 and 7.5 mg/kg). The body weight, and renal weight were estimated. The inflammatory cytokines, renal biomarkers, inflammatory antioxidant, and urine parameters were estimated. Results: Result showed that ellipticine considerably enhanced the body weight and reduced the renal tissue weight. Ellipticine treatment significantly (P < 0.001) repressed the level of blood urea nitrogen, serum creatinine, uric acid, blood glucose and altered the lipid parameters. Ellipticine significantly (P < 0.001) repressed the level of malonaldehyde and boosted the glutathione, catalase, superoxide dismutase, and glutathione peroxidase. Ellipticine treatment significantly (P < 0.001) reduced the inflammatory cytokines and inflammatory mediators. Conclusions: Ellipticine could be a renal protective drug via attenuating the inflammatory reaction, fibrosis and oxidative stress in streptozotocin induced rats.

SUMMARY: This study aims to investigate the effect of Tangzhouling on the morphological changes of Nissl bodies in the dorsal root ganglion of DM Rats. In this study, 69 rats were randomly divided into a control group (n = 10) and a model group (n = 59). The rats in the model group were randomly divided into a diabetic group (n = 11), a vitamin C group (n = 12), a low dose Tangzhouling group (n = 12), a medium dose Tangzhouling group (n = 12) and a high dose Tangzhouling group (n = 12). The dose of Tangzhouling in the low dose group was 5 times that of the adult dose, being 0.44g/kg/d. The dose of Tangzhouling in the medium dose group was 10 times that of the adult dose, being 0.88g/kg/d. The dose of Tangzhouling in the high dose group was 20 times that of the adult dose, being 1.75g/kg/d. All doses above are crude drug dosages. Rats in the vitamin C group were given 10 times the dose of an adult, being, 0.05 g/ kg/d. The diabetic group and the control group were given the same amount of distilled water. Drug delivery time is 16 weeks. The dorsal root ganglion was placed in a freezing tube at the end of the experiment. The morphological changes of Nissl bodies in the dorsal root ganglion were detected by HE and Nissl staining. The study results showed that vitamin C had no significant effect on the quantity, size and nucleolus. Tangzhouling can improvee the morphology, quantity and nucleolus of Nissl bodies to a certain extent, and the high dose is better than the lower dose. Tangzhouling capsules can improve the nerve function of DM rats through Nissl bodies.

RESUMEN: Este estudio tuvo como objetivo investigar el efecto de Tangzhouling en los cambios morfológicos de los cuerpos de Nissl en el ganglio de la raíz dorsal de las ratas DM. En este estudio, 69 ratas se dividieron aleatoriamente en un grupo control (n = 10) y un grupo modelo (n = 59). Las ratas del grupo modelo se dividieron aleatoriamente en un grupo diabéticos (n = 11), un grupo vitamina C (n = 12), un grupo de dosis baja de Tangzhouling (n = 12), un grupo de dosis media de Tangzhouling (n = 12) y un grupo de dosis alta de Tangzhouling (n = 12). La dosis de Tangzhouling en el grupo de dosis baja fue 5 veces mayor que la dosis del adulto, siendo 0,44 g/kg/d. La dosis de Tangzhouling en el grupo de dosis media fue 10 veces mayor que la dosis del adulto, siendo 0,88 g/kg/d. La dosis de Tangzhouling en el grupo de dosis alta fue 20 veces mayor que la dosis del adulto, siendo 1,75 g/kg/d. Todas las dosis anteriores son dosis de fármaco crudo. Se les administró 10 veces la dosis de un adulto a las ratas del grupo vitamina C, siendo 0,05 g/kg/d. El grupo de diabéticos y el grupo de control recibieron la misma cantidad de agua destilada. El tiempo de entrega del fármaco fue de 16 semanas. El ganglio de la raíz dorsal se colocó en un tubo de congelación al final del experimento. Los cambios morfológicos de los cuerpos de Nissl en el ganglio de la raíz dorsal se detectaron mediante tinción de HE y Nissl. Los resultados del estudio mostraron que la vitamina C no tuvo un efecto significativo sobre la cantidad, el tamaño y el nucléolo. Tangzhouling puede mejorar la morfología, la cantidad y el nucléolo de los cuerpos de Nissl hasta cierto punto, y es mejor la dosis alta que la dosis baja. Las cápsulas de Tangzhouling pueden mejorar la función nerviosa de las ratas DM a través de los cuerpos de Nissl.

Abstract This study aims to explore the molecular mechanism of neuronal axonal lesions caused by high glucose, and to investigate the protective effect of Lycium barbarum polysaccharide (LBP) on neuronal axon damage with in vitro models. A rat model of type II diabetic encephalopathy was established, and the rats were treated with LBP for 10 weeks. Morris water maze experiment was used to detect spatial learning and memory ability. Neuronal axon lesions were measured by in vivo neuron tracing experiment. Immunohistochemistry and Western-blot technology were employed to detect protein localization and expression. Combined with in vitro primary neuron culture, total internal reflection fluorescence microscopy was used to detect the effects of high glucose and LBP on neuronal axon transport. PI3K inhibitors LY294002 and an activator of insulin signaling pathway were used to investigate the possible molecular mechanism. In vivo and in vitro experiments showed that in the hippocampus tissue of STZ-induced type II diabetic encephalopathy model rats, neuronal axons were damaged, accompanied by hyperphosphorylation of Tau protein, which subsequently resulted in axonal transport damage and cognition dysfunction. LBP significantly reduced peripheral blood glucose and serum insulin levels in type II diabetic encephalopathy model rats, thereby alleviating peripheral insulin resistance. At the same time, LBP can significantly improve the learning and memory impairment and brain neuron axon pathology in model rats. LY294002 treatment can effectively block the PI3K/Akt signaling pathway. The phosphorylation level of Tau protein in the LY294002+ LBP treatment group is higher than that of the LBP intervention group, while the insulin treatment can effectively reverse the blocking effect of LY294002 on LBPs. LBP can reduce the phosphorylation level of Tau protein by up-regulating the PI3K/Akt/GSK3β signaling pathway, with a protective effect on neuronal axon damage, thereby improving the cognitive function performance of type II diabetic encephalopathy model rats.

ABSTRACT Purpose: To analyze the effect and mechanism of dexmedetomidine (DEX) analgesia pretreatment on functional chronic visceral pain in rats. Methods: Rats were divided into six groups: W1, W2, W3, W4, W5, and W6. The behavioral changes and electrophysiological indexes of rats in each group before and after DEX treatment were detected. Results: The levels of abdominal withdrawal reflex (AWR) in W5 and W6 groups were significantly lower than those in group W3, while the levels of thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT) were significantly higher than those in group W3 (p < 0.05). The electromyographic signals of W1, W5, and W6 groups showed little fluctuation, while those of groups W2, W3, and W4 showed obvious fluctuation. TLR4 mRNA expression, IRF3, P65, and phosphorylation levels in W4, W5, and W6 groups were significantly lower than those in group W2 (p < 0.05). Conclusions: Dexmedetomidine epidural anesthesia pretreatment could significantly inhibit visceral pain response in rats with functional chronic visceral pain, and its mechanism was related to the activation of TLR4 in spinal dorsal horn tissue of rats and the activation inhibition of IRF3 and P65 in the downstream key signals.

Abstract Background: Phospholipase C-like 1 (PLCL1), a protein that lacks catalytic activity, has similar structures to the PLC family. The aim of this research was to find the function and underlying mechanisms of PLCL1 in fibroblast-like synoviocyte (FLS) of rheumatoid arthritis (RA). Methods: In this study, we first analyzed the expression of PLCL1 in the synovial tissue of RA patients and K/BxN mice by immunohistochemical staining. Then silencing or overexpressing PLCL1 in FLS before stimulating by TNF-α. The levels of IL-6, IL-1β and CXCL8 in FLS and supernatants were detected by Western Blot (WB), Real-Time Quantitative PCR and Enzyme Linked Immunosorbent Assay. We used INF39 to specifically inhibit the activation of NLRP3 inflammasomes, and detected the expression of NLRP3, Cleaved Caspase-1, IL-6 and IL-1β in FLS by WB. Result: When PLCL1 was silenced, the level of IL-6, IL-1β and CXCL8 were down-regulated. When PLCL1 was overexpressed, the level of IL-6, IL-1β and CXCL8 were unregulated. The previous results demonstrated that the mechanism of PLCL1 regulating inflammation in FLS was related to NLRP3 inflammasomes. INF39 could counteract the release of inflammatory cytokines caused by overexpression of PLCL1. Conclusion: Result showed that the function of PLCL1 in RA FLS might be related to the NLRP3 inflammasomes. We finally confirmed our hypothesis with the NLRP3 inhibitor INF39. Our results suggested that PLCL1 might promote the inflammatory response of RA FLS by regulating the NLRP3 inflammasomes.

RESUMEN Un deslizamiento de tierra ocasionó un flujo de detritos a una escala de 0.3 miles de millones de metros cúbicos en la hondonada de Zhamunong en el río Yigong, el 9 de abril de 2000. El estudio de los factores deteterminantes y las dinámicas del proceso de este desastre, al igual que el estudio de la tendencia a futuro de eventos similares, ha sido de gran importancia científica e ingenieril. Inicialmente, se recolectó la información relacionada con la precipitación, terremotos y temperatura antes del deslizamiento y la información de onda sísmica después del evento. Luego se realizó un acercamiento multidimensional a la información para encontrar los factores, los procesos dinámicos y la tendencia del deslizamiento de tierra que desencadenó un flujo de detritos en Zhamunong, y que incluyó el índice de precipitación regular y los métodos de cálculo de aceleración sísmica, transformada rápida de Fourier, estabilidad de un deslizamiento, el método de las diferencias finitas MacCormack-TVD y el método de simulación numérica FLAC. Los resultados muestran lo siguiente: (1) Los factores de control principal del deslizamiento fueron el ciclo a largo plazo de congelación y descongelación, el ciclo de humedad y sequía, y un terremoto de magnitud media. (2) Con base en el espectro de vibración del terreno registrado durante este evento por la estación sísmica de Linzhi, las dinámicas pasan por el desarrollo del proceso de agrietamiento y articulación, el proceso de agrietamiento de las fracturas y deslizamiento, la traslación del deslizamiento de tierra en flujo de detritos, el movimiento y la deposición de estos detritos. (3) La densidad y el promedio de velocidad son de 2.0 tm-3 y 30.12 ms-1, y la descarga se muestra con el proceso de primero incremento y luego disminución. (4) Eventos similares pueden ocurrir en la hondonada de Zhamunong a futuro. Los resultados de la investigación son útiles para establecer los cimientos de estudios posteriores en los mecanismos de dinámicas y en la reducción de contramedidas de deslizamienos de tierra ocasionados por flujos de detritos.

ABSTRACT A disaster of a catastrophic landslide triggered a debris flow with a scale of 0.3 billion m3 that occurred in the Zhamunong gully of Yigong on April 9th, 2000. It is of great scientific and engineering significance to study the main controlling factors and dynamic processes of this disaster, and the future development trend of similar hazards. Firstly, the precipitation, earthquake and temperature data before the event and seismic wave data after the event were collect. Secondly, a multi-dimensional approach on the data for finding the factors, dynamic processes and tendency of a catastrophic landslide triggered a debris low in Zhamunong gully was applied, including the standard precipitation index and effective peak acceleration calculation methods, fast Fourier transform, landslide stability, MacCormack-TVD finite difference method and FLAC numerical simulation method. The results are shown as follows. (1) The main controlling factors of this disaster were the long-term freeze-thaw cycle, dry-wet cycle, and a middle magnitude earthquake. (2) Based on the ground vibration spectrum of 2000 disaster recorded by the Linzhi seismic station, the dynamic processes are the joint and crack development process, the crack fracture and sliding process, the landslide translating into the debris flow, the movement and deposition of the debris flow. (3) The density and the average velocity are 2.0 tm-3 and 30.12 ms-1, respectively, and the discharge is shown with the process of first increases and then decreases. (4) Similar catastrophic landslide triggered debris flow would happen in Zhamunong gully in the future. The research results are useful in establishing a foundation for further study on the dynamic mechanism and reduction countermeasures of a catastrophic landslide triggered by debris low.

RESUMEN A través de la regularización de la gravedad y las anomalías magnéticas, se puede resolver la profundidad de la fuente del campo. Sin embargo, debido al efecto Gibbs, el poder de resolución horizontal de la fuente de campo es poco. En vista de esto, basado en la profundidad de la fuente de campo establecida por la continuación de la regularización hacia abajo, este artículo propone un método de inversión de parámetros de propiedades físicas basado en la continuación iterativa y la separación de anomalías, que puede mejorar efectivamente la precisión de inversión de los parámetros físicos de anomalías superpuestas, y proporcionar una nueva idea para resolver los parámetros físicos de la superposición de gravedad y anomalías magnéticas.

ABSTRACT Through the regularization downward continuation of gravity and magnetic anomalies, the depth of the field source can be solved. However, due to the Gibbs effect, the horizontal resolving power of the field source is poor. In view of this, based on the depth of field source established by regularization downward continuation, this paper proposes a physical property parameter inversion method based on iterative continuation and anomaly separation, which can effectively improve the inversion accuracy of superimposed anomaly physical parameters, and provide a new idea for solving the physical parameters of superposition gravity and magnetic anomalies.

ABSTRACT Objective This study aims to investigate the association of filamin A with the function and morphology of prostate cancer (PCa) cells, and explore the role of filamin A in the development of PCa, in order to analyze its significance in the evolvement of PCa. Materials and Methods A stably transfected cell line, in which filamin A expression was suppressed by RNA interference, was first established. Then, the effects of the suppression of filamin A gene expression on the biological characteristics of human PCa LNCaP cells were observed through cell morphology, in vitro cell growth curve, soft agar cloning assay, and scratch test. Results A cell line model with a low expression of filamin A was successfully constructed on the basis of LNCaP cells. The morphology of cells transfected with plasmid pSilencer-filamin A was the following: Cells were loosely arranged, had less connection with each other, had fewer tentacles, and presented a fibrous look. The growth rate of LNCap cells was faster than cells transfected with plasmid pSilencer-filamin A (P <0.05). The clones of LNCap cells in the soft agar cloning assay was significantly fewer than that of cells stably transfected with plasmid pSilencer-filamin A (P <0.05). Cells stably transfected with plasmid pSilencer-filamin A presented with a stronger healing and migration ability compared to LNCap cells (healing rate was 32.2% and 12.1%, respectively; P <0.05). Conclusion The expression of the filamin A gene inhibited the malignant development of LNCap cells. Therefore, the filamin A gene may be a tumor suppressor gene.

ABSTRACT The production of Camellia oleifera (oil tea), typically planted in acidic red soils in southern China, is limited by low soil fertility. Agro-farming is one way to promote soil fertility by increasing organic matter and microbial communities. To understand the impact of agro-farming activity on soil fertility, three types of agro-farming, namely, raising laying hens under forest (RLH), cultivating Lolium perenne grass under forest (LPG), and maintenance of native grass (MNG), were employed in an oil tea farm with acidic red soil in Changsha, China. Soil samples were collected from the farm to estimate microbial communities, pH, and total organic carbon (TOC) in different seasons. The results indicated that TOC and temperature were the dominant factors influencing the variations of bacterial communities, while temperature and pH affected the fungal communities in the soil. The most abundant bacterial phyla were Acidobacteria, Proteobacteria, Actinobacteria, and Chloroflexi , while the most abundant fungal phyla were Ascomycota, Basidiomycota, and Zygomycota . Regardless of treatment, the bacterial richness and diversity were both low in spring, and the fungal richness and diversity in summer and autumn were higher than in spring and winter. The TOC content and pH in LPG were significantly higher than in other treatments. Microbial communities in LPG and MNG were more stable than in RLH. In summary, cultivating grass under forest treatment was the best way to improve the microenvironment with the highest TOC content and fewer pathogenic microorganisms.

The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified. We did not gain additional information by contacting the authors of the primary studies. Two reviewers independently extracted the data and evaluated study quality. This meta-analysis was executed to determine the odds ratio, mean difference, standardized mean difference, and 95% confidence intervals with random-effects models. In total, 8 randomized trials including 524 patients met the inclusion criteria. There were significant differences in fracture healing time, pain relief and function improvement. There were no significant differences in the fracture healing rate or adverse events, including light-headedness, hypercalcemia, nausea, sweating and headache, except for slight bruising at the injection site. We determined that the effectiveness and safety of PTH in fracture healing is reasonably well established and credible.

ABSTRACT Phleum paniculatum Huds., commonly known as British timothy, is an increasingly serious weed in wheat field of China. However, the biology of its seed germination and seedling emergence remain unclear. In the present study, the effects of environmental factors on seed germination and seedling emergence of P. paniculatum were explored. Phleum paniculatum seeds had a shallow dormancy (20-30 d) when stored at room temperature (25 ± 5 °C). Seeds could germinate at constant temperatures between 10 and 25 °C, except for 5 or 30 °C. Light was not essential for seed germination, and pH values from 4 to 10 did not inhibit germination. Seeds were moderately adaptable to water potential and NaCl concentration, and germination rates would be decreased 50% when water potential was -0.4 MPa or NaCl concentration was 130 mM. Increased soil burial depth decreased the seedling emergence, and no seeds emerged when the burial depth was more than 4 cm. Taken together, our results provide useful information of the germination and emergence of P. paniculatum seed, and strategies such as proper drainage systems managed and deep plowing are recommended to limit its detrimental effects on agricultural production.

ABSTRACT The N absorption and assimilation is critical for the rice (Oryza sativa L.) yield increase when overdose N was applied in rice production. Three different rice genotypes, 'Quanliangyou 1' (Q1), 'Quanliangyou 681' (Q681) and 'Huanghuazhan' (HHZ), were selected to investígate the effects of elevated N input on the N partitioning, plant growth, grain quality and key genes involved in glutamate biosynthesis. Under increasing N inputs (0, 120, 180, 250 kg ha-1), N content in leaf, culm, seed and root were increased significantly. The increased N was preferentially deposited in leaf and culm. Tiller number, panicle number and length were also proved to be significantly promoted, but plant height and 1000-grain weight were nonsignificantly affected under elevated N input. Under high N input, seed protein content was elevated, while fatty acid and amylose content remained unchanged in comparison to low N input, but amylopectin content decreased. For the key genes in N assimilation, glutamine synthetase (OsGS1;1) could be induced by increasing N input (0 to 180 kg ha-1) but higher N input (250 kg ha-1) inhibit its expression, which showed similar response pattern with the glutamine synthetase activity. Although different rice genotypes showed similar response pattern to elevated N input, each genotype varied a lot in certain phenotypic indexes. And the response pattern of all these phenotypic characteristics to elevated N input was independent of rice genotype. These findings suggest that elevated N input could promote rice growth, reallocate N content in different tissues, and have negative impact on grain quality. This study provided physiological and molecular foundation for rice breeding and cultivation under high N input.

Insomnia is highly prevalent in children and adolescents. However, the efficacy of cognitive behavioral therapy for insomnia (CBT-i) in children and adolescents remains controversial. Therefore, this systematic review and meta-analysis aimed to assess the efficacy of CBT-i in children and adolescents. We conducted a search of PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, and PsycINFO to select primary studies evaluating CBT-i in children and adolescents that were primarily diagnosed through standardized diagnostic criteria. The primary outcomes of the meta-analysis included sleep onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), and sleep efficiency (SE%). Six randomized controlled trials and four open-label trials met all inclusion criteria. A total of 464 participants (ranging from 5–19 years of age) were included. Based on the results from sleep logs, a significant pooled effect size was observed for SOL and SE%. However, no significant pooled effect size was found for WASO or TST. Results from actigraphy were consistent with the sleep logs. A significant pooled effect size was observed for SOL and SE%, and no significant pooled effect size was found for WASO or TST. CBT-i might be effective in the treatment of children and adolescents with insomnia.

Rhabdomyolysis refers to the destruction or disintegration of striated muscles. This syndrome is characterized by muscle breakdown and necrosis, resulting in the leakage of intracellular muscle constituents into the circulation and extracellular fluid. We report a rare case of rhabdomyolysis complicating multi-organ failure caused by T-cell lymphoma in a 32-year-old woman. The final diagnosis was rhabdomyolysis caused by peripheral T-cell lymphoma based on bone marrow aspirate and biopsy.